Proper gastrointestinal motility is essential for optimal rates of nutrient and fluid absorption, elimination of toxins and overall abdominal comfort. GI motility is regulated by over 100 million neurons embedded in the walls of the GI tract. Collectively known as the enteric nervous system, or the “gut brain,” these neurons communicate by way of numerous neurotransmitters and neurohormones to coordinate smooth muscle contraction. Serotonin and acetylcholine are the principal neurotransmitters within the GI tract that stimulate motility. Conversely, melatonin helps to modulate these signals to maintain slower neuromuscular rhythms.
MotilPro supports serotonergic and cholinergic neurotransmission in the GI tract. 5-HTP is absorbed by enterochromaffin cells in the epithelium, in which it is decarboxylated to serotonin using pyridoxal
5’ phosphate as a cofactor. 5-HTP stimulates enteric neurons through activation of 5HT4 receptors.(3,4) Ginger modulates serotonin signaling by additional 5HT4 stimulation and by binding type 3 (5HT3) receptors in the enteric nervous system and brain stem, supporting gastric emptying, intestinal transit, healthy visceral sensation and upper GI comfort.(5,6) Acetyl-l-carnitine supports autonomic neuronal health and contributes acetyl groups for the synthesis of acetylcholine.