Select Page

Neurotransmitters Test Kit


The NeuroAdvanced Profile includes the following dried urine tests: GABA, Glu, Gly, DA, Epi, NE, HIST, 5-HT, PEA, DOPAC, HVA, 5-HIAA, NMN, VMA & Crtn 

Neurotransmitters are chemical messengers used by the nervous system to relay information from one nerve to another. Optimal neurotransmitter balance is required to maintain proper health. Imbalances can cause the brain and the body to be over- or under-stimulated, producing neurological or psychological symptoms.

This testing reveals an individual’s level of neurotransmitters, the body’s chemical messengers that influence mental processes, energy and emotions. Learn if you’re in the 86% of Americans who have suboptimal neurotransmitter levels.

Urine testing is the most common method for testing neurotransmitters. Patients collect urine on a filter strip up to four times during the day. Dried strips are shelf-stable for 30 days and easy to mail to the lab for analysis. the-science-of-dried-urine-testing-provider-data-sheet


Optional add-on tests for this kit:

  • Saliva Hormones add-on – E2, Pg, T, DS & C
  • Urine Hormones add-on – E2, Pregnanediol, Allopregnanolone, Androstenedione, T, Epi-T, DHT, DHEA, & 5α,3α-Androstanediol
  • Diurnal Cortisol add-on – Free Cortisol x 4 & Free Cortisone x 4
  • Diurnal Cortisol & Melatonin add-on – Free Cortisol x 4, Free Cortisone x 4 & Melatonin (MT6s) x 4
  • Diurnal Cortisol, Norepinephrine & Epinephrine add-on – Free Cortisol x 4, Free Cortisone x 4, NE x 4 & Epi x 4
  • Diurnal Cortisol, Melatonin, Norepinephrine & Epinephrine add-on – Free Cortisol x 4, Free Cortisone x 4, Melatonin (MT6s) x 4, NE x 4 & Epi x 4
  • Urine Toxic & Essential Elements add-on – I, Se, Br, Li, As, Cd & Hg




Why is this test useful?

While parent neurotransmitters are helpful in assessing precursor availability, interpreting results based on those levels alone can result in undertreatment, treatment of the wrong part of the system, or overtreatment with direct precursors. It’s only by looking at the parent neurotransmitters with downstream metabolites that you can tell whether there is a systemic pattern.

Given the importance of these levels to correct interpretation of neurotransmitter results and subsequent treatment plans, ZRT Laboratory includes a range of 14 neurotransmitters and metabolites in its testing. This essential collection of tests is available only from ZRT – and not from any other lab.

How a Dysregulated Nervous System Impacts Health

Genetics, environment, chemicals and nutritional deficiencies are a few factors that can impact neurotransmitter production. Once out of balance, the nervous system begins to compensate – which, in time, can lead to neurological or psychological symptoms.

Some of the more common psychological conditions today are known to be accompanied by neurotransmitter imbalances. However, it’s also possible for individuals to present with similar symptoms yet have unique foundational imbalances. Testing helps clarify these root issues.

Common neurotransmitter-related causes of health issues often involve the following scenarios:

  • Anxiety & Depression: Neurotransmitter imbalances are often associated with anxiety and depression, specifically Glutamate (panic attacks), PEA, Histamine, Serotonin, as well as Epinephrine & Norepinephrine.
  • Chronic Fatigue: An imbalance between excitatory and inhibitory neurotransmitters can lead to persistent fatigue.
  • Impulsivity: GABA, Dopamine and Serotonin are three chemical messengers commonly linked to disorders like ADD, ADHD & OCD.
  • Insomnia: Imbalances in Glutamate, Histamine, Dopamine, GABA and Serotonin are often linked to sleep disturbances and insomnia.
  • PMS or PMDD: Imbalances in Serotonin, Dopamine, Norepinephrine and GABA are often involved in cases of PMDD (pre-menstrual dysphoric disorder) and severe PMS.
Testing Hormones with Neurotransmitters

In the neurological system, hormones are synergistic with neurotransmitters – modulating their production, signaling and metabolism. Because of this complex interplay, testing hormones and neurotransmitters together is an ideal way to generate a more precise clinical assessment. This combined testing gives practitioners a diagnostic edge over the traditional psychological inventory and offers the advantage of zeroing in on which therapies are best suited for individual patients – cutting down on the time-consuming process of trial-and-error for identifying treatment options.

Testing Elements with Neurotransmitters

Heavy metals are damaging to brain health. They disrupt neurotransmitter function and create oxidative stress that is detrimental to nerve cells, contributing to mood disorders, poor memory and dementia. Identifying exposure to heavy metals may be key to assessing and treating mood disorders and preventing neurodegenerative diseases. In contrast, nutritional elements are generally protective for brain health. Lithium acts directly on the brain by slowing the progression of dementia and stabilizing mood, while elements like iodine and selenium act indirectly by supporting healthy thyroid and brain function.


ZRT is a CLIA certified diagnostic laboratory and the leader in hormone and wellness testing. They provide accurate and meaningful test results that assist health care providers in making informed treatment decisions. Test kit is provided through Coast to Coast Compounding, a licensed pharmacy in the State of Colorado and test results will be sent back to Coast to Coast Compounding.  A pharmacist will reach out to you to discuss your test kit prior to shipping and after the completed.  *Not available to residents in California, New York and Maryland. **Product is cash pay and will not billable to your insurance.


Click here to see a video on how to collect your sample:

You may also like…