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What is pregnenolone?

Microscopic image of pregnenolone

Pregnenolone is a steroid hormone secreted by the adrenal gland. Steroids are the large family of structurally similar biochemicals that have sex-determining, anti-inflammatory, and growth regulatory roles in our body. Like DHEA and other hormones, pregnenolone levels drop in our bodies with age. Pregnenolone can be synthesized in the laboratory and sold as supplements, however, there is not much information regarding how pregnenolone supplements might work.

How Pregnenolone is produced

Laboratory scientist looking at a capsule with chemical structures surrounding it

The adrenal gland produces pregnenolone from cholesterol. It is the starting material for other hormones, also called a precursory hormone, from which all other hormones like estrogen, testosterone, cortisol, and DHEA are made. Pregnenolone is an abundant chemical in the brain where it facilitates communication between brain cells and improves the transmission of nerve cells. Pregnenolone and DHEA are considered neurosteroids and are associated with functions like cognitive performance, response to stress, and mood regulation. 

Low Pregnenolone level

Pregnenolone levels decline as much as 60% as we age. Low pregnenolone levels are considered a significant contributing factor in depression. Adrenal stress may also cause a decline in pregnenolone levels. Low pregnenolone levels in women could, in turn, cause a lack of estrogen. 

Common Symptoms of Low Pregnenolone
  • Moodiness
  • Absence of mind
  • Short-term memory failure
  • Depression
  • Cluster headaches

Woman with her eyes closed and feeling her forehead

Pregnenolone supplements

Supplements in a bowl

Pregnenolone supplements are considered an anti-aging compound and are commonly used for potentially fighting fatigue, restoring energy, enhancing memory, and also for improving immunity.

Pregnenolone supplements can be purchased as dietary supplements. Women use them for support the menopause process, other hormone productions and help people feel younger and more energized. However, no clear evidence supports these claims. 

Hormone Testing Available

At Coast to Coast Compounding we can provide you with an at-home testing kit which can allow you to test your own hormone levels. Speak with one of our knowledgeable pharmacists or your healthcare provider for more information on using one of these testing kits. Click here for more information on how to get your hormones tested.

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